25.04 – 26.04.2019 – ASTOX Symposium 2019

Programme

Session 1: Chemical Mixtures

• Keynote Lecture – The EFSA Guidance on risk assessment for human, managed animals, and ecosystems of combined exposure to multiple chemicals
• ChemCock: Introduction to the Austrian project on chemical mixtures
• ChemCock: The modified Reference Point Index (mRPI) – an Approach to Assess Risks of Food Contaminant Mixtures
• ChemCock: Some examples for cumulative risk assessment of chemical mixtures of contaminants
• Keynote Lecture – The EuroMix test strategy to generate data for future mixture risk assessment

Session 2: Biotoxins

• Use of Next Generation Sequencing to identify the molecular basis of disorders
• Cell Membrane: structure and biophysical properties determining response to toxicants
• Toxicological characterisation of mycotoxins and their degradation products
• Insights into the toxicity of prymnesins, toxic metabolites of the microalgae Prymnesium parvum
• Immunomodulatory effects of the Fusarium secondary metabolite butenolide in human colon epithelial cells
• Combinatory Effects of Deoxynivalenol and the Emetic Bacterial Toxin Cereulide on Cell Viability of Caco-2 Monolayers

Session 3: Hot Topics

• Biological connectivity and the exposome: a paradigm shift towards precision prevention
• Global metabolomics as a key technology for deciphering toxin exposure and effect
• Fate of the mycotoxin deoxynivalenol during baking
• Review of maximum residue levels of tau-fluvalinate according to Regulation (EC) No 396/2005
• Acid protective formulation of omeprazole using β-lactoglobulin and mesoporous silica nanoparticles: insightful in vitro release, cytotoxicity and mitochondrial morphology effects
• Mercury-containing Creams – Not only a Problem for the User!

Session 4: Medicinal Products

• Facing challenges transitioning from basic research to early non-clinical development
• ADME in Safety Testing of Pharmaceuticals, something to talk about?
  Dr. Gerhard Hager
• Marketing surveillance of medicinal products (legal & illegal market)
• The Environmental Risk Assessment of Human Medicinal Products
• Impact of coccidiostats on the environment, ecotoxicological aspects

Session 5: Perfluorinated Alkylated Substances

• Tackling Perfluorinated Alkylated Substances: A Brief Update on the Toxicity of this Compound Class and on Regulatory Activities
• Occurrence of per- and polyfluoroalkyl substances (PFAS), chemicals with known endocrine disrupting activity, in drinking water, groundwater and surface water, Austria 2017/2018
• Human Biomonitoring of perfluoroalkyl substances within HBM4EU and in Austria
• Exposure to perfluoralkyl substances (PFAS) of pregnant women and its potential impact on fetal growth
• Effects of PFAS on placental vascularization